Diclofensine

Research chemical

A triple monoamine reuptake inhibitor developed by Hoffman-LaRoche in the 1970s as an antidepressant but discontinued, probably due to high abuse potential. Has not become popular as a recreational drug at this time. Acts as an SNDRI, mostly inhibits dopamine and noradrenaline.

ro8-4650

Extended library — TripSit data only (PolyForm Noncommercial 1.0.0).

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.

Dose

Published population range

Threshold12 mg

Light30–40 mg

Common40–60 mg

Heavy / risk zone60–80 mg

No weight-based model. Unknown potency — start far below any published figure.

Check an amount you already have

Harm reduction

This entry comes from the extended library: it is a less-studied substance with fewer independent sources.
Unknown potency is the main risk with novel substances — start with a fraction of any published figure and never re-dose before the full onset has passed.
Test with reagents and, where possible, a lab service. Fentanyl and nitazene contamination is not detectable by eye or by reagent alone.
Avoid using alone, and do not combine with other drugs while you are learning how a new substance affects you.

Sources

• TripSit wiki (PolyForm Noncommercial)
https://wiki.tripsit.me

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.