Clomethiazole

Research chemical

Structurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute alcohol withdrawal.

Extended library — TripSit data only (PolyForm Noncommercial 1.0.0).

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.

Dose

Published population range

Threshold100 mg

Light100–150 mg

Common150–200 mg

Heavy / risk zone≥ 200 mg

No weight-based model. Unknown potency — start far below any published figure.

Check an amount you already have

Expected effects

Anxiolytic
Sedative
Muscle relaxant
Amnesia
Dystaxia
Hypnotic

Harm reduction

This entry comes from the extended library: it is a less-studied substance with fewer independent sources.
Unknown potency is the main risk with novel substances — start with a fraction of any published figure and never re-dose before the full onset has passed.
Test with reagents and, where possible, a lab service. Fentanyl and nitazene contamination is not detectable by eye or by reagent alone.
Avoid using alone, and do not combine with other drugs while you are learning how a new substance affects you.

Sources

• TripSit wiki (PolyForm Noncommercial)
https://wiki.tripsit.me

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.