Tapentadol

Opioid

An opioid analgesic drug with potency somewhere between tramadol and morphine, and with a similar action to Tramadol. Also an adrenergic reuptake inhibitor. High addiction potential. Potential for respiratory depression in overdose. Should not be combined with depressants or stimulants.

NucyntaPalexiaYantilYantil SR

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠Dose here depends overwhelmingly on your tolerance, not your body weight. A dose that is mild for a tolerant user can be fatal for someone else.

⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold12.5 mg

Light25–50 mg

Common50–75 mg

Strong75–150 mg

Heavy / risk zone≥ 150 mg

Basis: Tolerance dominates.

Seizure risk at higher doses.

Check an amount you already have

Timeline (oral)

Onset15–30 minutes

Come-up30–45 minutes

Peak60–120 minutes

Offset120–180 minutes

Total240–360 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

Analgesia
Euphoria

Possible side effects

Seizure risk at higher doses
Respiratory depression
Nausea
Serotonin syndrome risk
Dependence

Known toxicity

low toxicity
potentially lethal when mixed with depressants like alcohol or benzodiazepines

Harm reduction

Never use alone. The single most effective thing you can do is have someone with you or on the phone.
Carry naloxone and know how to use it. It reverses opioid overdose and cannot harm someone who has not taken opioids.
Use fentanyl and nitazene test strips on every batch, including pills. They catch a large share of contamination, though not all of it.
Start with a fraction of your usual amount when you get a new batch or after any break in use - tolerance drops fast, in days.
Do not mix with benzodiazepines, alcohol, GHB or other sedatives. That combination is behind the majority of opioid deaths.
If someone is unresponsive: call emergency services, give naloxone, put them in the recovery position and stay with them. Naloxone wears off before many opioids do, so a second dose may be needed.
Prescribed opioid medication should never be shared or stockpiled - tolerance differences make it lethal.

Identify what you have

Marquis (reacts)magenta - reddish purple (68)

Mecke (reacts)light purple (10)

Mandelin (reacts)blue-gray (greenish) (12)

Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.