DOSINA

Quetiapine

Medication

An antipsychotic (prescription medicine) often used off-label at low doses as a sleep aid. Included for interaction checking.

Seroquelseroquel

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Prescription or supplement entry — included for interaction checking, not as recreational dose guidance. Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.
⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold10 mg
Light25–50 mg
Common50–150 mg
Strong150–300 mg
Heavy / risk zone≥ 300 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (oral)

Onset20–40 minutes
Peak90–360 minutes
Offset360–420 minutes
Afterglow1440–2880 minutes
Total480–1440 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Sedation, antipsychotic effect (prescription medicine)

Possible side effects

  • Heavy sedation
  • Low blood pressure on standing
  • Metabolic effects with long-term use
  • Used 'off-label' at low doses as a sleep aid

Known toxicity

  • low toxicity

Harm reduction

  • Dosina shows prescription medicines so their interactions are visible - not so you can use them recreationally.
  • Never stop a prescribed medicine abruptly to take something else. Antidepressant discontinuation syndrome is real and can be severe; talk to your prescriber first.
  • SSRIs, SNRIs, MAOIs, lithium and tricyclics all interact with recreational drugs in ways that range from 'wastes your money' to 'kills you'.
  • Serotonin syndrome is the emergency to watch for: agitation, confusion, tremor, sweating, muscle rigidity, fever and a fast heartbeat after combining serotonergic drugs. It can become fatal within hours.
  • Keep any prescription medicine in its original packaging and never share it.

Mixing

DepressantsDangerous

See interaction notes for details.

StimulantsCaution

See interaction notes for details.

DissociativesCaution

See interaction notes for details.

Tolerance, dependence and detection

Toleranceback to baseline after 7 - 14 days
Addiction potentialmoderately physically and psychologically addictive

Sources

• PsychonautWiki — Quetiapine (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Quetiapine

• TripSit wiki — Quetiapine (PolyForm Noncommercial)
https://wiki.tripsit.me

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.