DOSINA

Mescaline

Psychedelic

Peyote is a small, spineless cactus that contains mescaline as its primary active chemical. It has a long history of use among the natives of northern Mexico and SW United States.

PeyoteSan PedroCactusButtons

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.
⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold50 mg
Light50–200 mg
Common200–400 mg
Strong400–800 mg
Heavy / risk zone≥ 800 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (oral)

Onset45–90 minutes
Come-up60–120 minutes
Peak240–360 minutes
Offset120–180 minutes
Afterglow360–2160 minutes
Total480–840 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Long-lasting visuals
  • Emotional and spiritual insight
  • Warmth

Possible side effects

  • Severe nausea and vomiting
  • Body load
  • Anxiety
  • Insomnia
  • Long duration

Known toxicity

  • toxic dose is unknown

Harm reduction

  • Set and setting shape a psychedelic experience more than the dose does. Plan the room, the music, the company and the exit before you take anything.
  • Have a sober person present, or at minimum someone who knows what you have taken and can be called.
  • Do not redose to 'make it stronger'. Tolerance to psychedelics develops within an hour, so a redose mostly extends the experience and increases the risk of a difficult one.
  • Avoid combinations with lithium (seizure risk) and tramadol, and be extremely careful with cannabis, which sharply intensifies the experience.
  • People with a personal or family history of psychosis, schizophrenia or bipolar disorder should not use psychedelics - this is the clearest contraindication in the literature.
  • Never drive, cycle or operate machinery, and do not take psychedelics in public places or around crowds you cannot leave.
  • Physically: expect dilated pupils, raised heart rate and reduced appetite. These are normal. Chest pain, fainting or seizure activity is not - get help.
  • Frequency matters: repeated use within days has sharply diminishing returns and increases the risk of persistent visual disturbances.

Mixing

ΑMTDangerous

See interaction notes for details.

TramadolUnsafe

See interaction notes for details.

5-MeO-xxTCaution

See interaction notes for details.

CannabisCaution

See interaction notes for details.

AmphetaminesCaution

See interaction notes for details.

CocaineCaution

See interaction notes for details.

MAOIsCaution

See interaction notes for details.

Tolerance, dependence and detection

Tolerancehalf tolerance after 3 days; back to baseline after 7 days
Addiction potentialnot habit-forming
After-effects6-8

Sources

• PsychonautWiki — Mescaline (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Mescaline

• TripSit wiki — Mescaline (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Peyote.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.