DOSINA

Paracetamol

Supplement

A common painkiller and antipyretic. Not psychoactive. Included because accidental liver damage from overdose is common — especially when combined with alcohol.

acetaminophentylenol

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Not covered by PsychonautWiki — data comes from TripSit. Prescription or supplement entry — included for interaction checking, not as recreational dose guidance. Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.

Dose

Published population range

Common200–500 mg
⚠NOTE: Maximum daily dose is 4g

No weight-based model for this substance — published ranges only.

Check an amount you already have

Expected effects

  • Pain and fever relief (no psychoactive effect)

Possible side effects

  • Liver damage in overdose - and the damage starts before any symptoms appear
  • Dangerous with alcohol or when taken repeatedly above the labelled maximum
  • Accidental overdose is common because it is combined with other medicines

Harm reduction

  • Supplements are not risk-free. St John's Wort, 5-HTP, MAO-B and MAO-A inhibitors interact seriously with recreational drugs.
  • Never take 5-HTP at the same time as MDMA or other serotonin releasers - the combination is implicated in serotonin syndrome. At most it is used in the days after, and even that is debated.
  • Melatonin and L-theanine are sedating; that is fine for sleep but adds to depressant load if you have been drinking.
  • Dose information here reflects general-use amounts from the sources, not an endorsement of using them in combination with other drugs.

Tolerance, dependence and detection

After-effects1-2

Sources

• TripSit wiki — Paracetamol (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Acetaminophen.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.