DOSINA

Nicotine

Stimulant · popular

A powerful dependence-forming stimulant. Effects are short, but the dependence is among the strongest of any drug. Vaping is less harmful than smoking but not harmless, and nicotine pouches deliver high doses fast.

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0).

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.

Dose

Published population range

Threshold0.2 mg
Light0.5–2 mg
Common2–4 mg
Strong4–6 mg
Heavy / risk zone≥ 6 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (buccal)

Onset3–15 minutes
Come-up3–15 minutes
Peak5–20 minutes
Offset60–120 minutes
Afterglow120–360 minutes
Total45–90 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Alertness and focus
  • Mild euphoria
  • Relaxation
  • Appetite suppression

Possible side effects

  • Dependence forms extremely quickly
  • Nausea and dizziness with first use
  • Raised heart rate and blood pressure
  • Insomnia
  • Irritability and anxiety on withdrawal
  • Long-term cardiovascular harm (smoking more than vaping)

Known toxicity

  • estimated oral LD50 of 6.5 - 13 mg/kg in humans

Harm reduction

  • Test your substance. Cocaine, amphetamine and MDMA powders are routinely cut with fentanyl or nitazenes, and stimulant pills are frequently counterfeits.
  • Do not mix stimulants with each other, with alcohol, or with MAOIs, SSRIs or tramadol - the cardiovascular and serotonin risks compound.
  • Watch body temperature. Overheating and dehydration cause more stimulant emergencies than heart attacks do. Take breaks, cool down with water and air, and sip (do not gulp) fluids.
  • Eat and sleep. Sleep deprivation plus stimulants is the standard route into stimulant psychosis.
  • Do not re-dose compulsively. Set a maximum before you start, and give it to someone else to hold you to.
  • Chest pain, severe headache, one-sided weakness, slurred speech or fainting are medical emergencies. Call for help immediately.
  • Nasal use damages the septum and sinuses; chronic use causes permanent damage that does not heal.

Tolerance, dependence and detection

Tolerancehalf tolerance after 3 - 7 days; back to baseline after 1 - 2 weeks
Addiction potentialextremely addictive with a high potential for abuse

Sources

• PsychonautWiki — Nicotine (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Nicotine

• TripSit wiki — Nicotine (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Nicotine.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.