DOSINA

Midazolam

Depressant

A common hypnotic, sedative and anxiolytic benzodiazepine. High doses may cause amnesia and loss of inhibitions. Unusually, it is water soluble, and commonly used as a premedication for sedation as the solubility makes it better for IV use than other benzodiazepines.

Versed

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.

Dose

Published population range

Threshold1 mg
Light1–2 mg
Common2–4 mg
Strong4–5 mg
Heavy / risk zone≥ 5 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (intravenous)

Onset4–6 minutes
Peak60–240 minutes
Offset30–90 minutes
Total120–360 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Rapid, heavy sedation

Possible side effects

  • Profound amnesia
  • Respiratory depression
  • Only appropriate in monitored medical settings
  • Dangerous with other depressants

Harm reduction

  • Depressants are the class where mixing kills most often: alcohol, benzodiazepines, GHB/GBL and opioids all suppress breathing when combined.
  • Never use alone. If you use alone, set up a check-in call with someone who will call emergency services if you do not answer.
  • Measure liquid doses with a syringe. Bottle caps, teaspoons and 'glugs' are how people take ten times the intended dose.
  • Sedation can be delayed. Do not re-dose before you can feel the previous dose fully.
  • Do not stop daily benzodiazepine or alcohol use abruptly - withdrawal can cause seizures and is potentially fatal. Taper with medical help.
  • Signs that someone needs emergency help: breathing slower than one breath every 4-5 seconds, blue lips, snoring that will not stop, unrousable, vomiting while unconscious.

Tolerance, dependence and detection

After-effects1-12

Sources

• PsychonautWiki — Midazolam (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Midazolam

• TripSit wiki — Midazolam (PolyForm Noncommercial)
https://wiki.tripsit.me

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.