DOSINA

Methaqualone

Depressant

A pharmaceutical depressant and sedative phased out due to the better safety profile of benzodiazepines, part of the Qualone group of substances. Now very rare, except in South Africa.

QuaaludesLudesMandraxSoporQuackVitamin QSoaperludesquaaludesqualudesmandrax

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.
⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold75 mg
Light150–300 mg
Common300–500 mg
Strong500–600 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (oral)

Peak120–240 minutes
Offset120–240 minutes
Afterglow360–480 minutes
Total300–480 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Sedation
  • Euphoria
  • Relaxation
  • Reduced inhibitions

Possible side effects

  • Extremely narrow margin before unconsciousness
  • Respiratory depression
  • Seizures and muscle spasms
  • Dangerous with alcohol and depressants
  • Dependence

Known toxicity

  • doses of over 300mg can be dangerous for first time users
  • safe at appropriate dosages

Harm reduction

  • Depressants are the class where mixing kills most often: alcohol, benzodiazepines, GHB/GBL and opioids all suppress breathing when combined.
  • Never use alone. If you use alone, set up a check-in call with someone who will call emergency services if you do not answer.
  • Measure liquid doses with a syringe. Bottle caps, teaspoons and 'glugs' are how people take ten times the intended dose.
  • Sedation can be delayed. Do not re-dose before you can feel the previous dose fully.
  • Do not stop daily benzodiazepine or alcohol use abruptly - withdrawal can cause seizures and is potentially fatal. Taper with medical help.
  • Signs that someone needs emergency help: breathing slower than one breath every 4-5 seconds, blue lips, snoring that will not stop, unrousable, vomiting while unconscious.

Identify what you have

Marquisno color change (254)
Meckeno color change (221)
Mandelin (reacts)Very orange yellow (26)
Simon'sno blue color change (163)

Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.

Mixing

DepressantsDangerous

See interaction notes for details.

DissociativesDangerous

See interaction notes for details.

StimulantsCaution

See interaction notes for details.

Tolerance, dependence and detection

Tolerancehalf tolerance after 3 - 7 days; back to baseline after 1 - 2 weeks
Addiction potentialextremely addictive
After-effects4-6

Sources

• PsychonautWiki — Methaqualone (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Methaqualone

• TripSit wiki — Methaqualone (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Methaqualone.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.