Methamphetamine

Stimulant · popular

A longer-acting, more potent and more addictive stimulant than amphetamine. Euphoria and drive for many hours, followed by a severe crash, sleep deprivation and a real risk of psychosis with prolonged use.

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Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0).

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.

⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold5 mg

Light5–10 mg

Common10–30 mg

Strong30–60 mg

Heavy / risk zone≥ 60 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (insufflated)

Onset3–5 minutes

Come-up3–5 minutes

Peak90–180 minutes

Offset120–240 minutes

Afterglow360–1440 minutes

Total240–420 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

Very strong euphoria
Extreme energy and drive
Alertness lasting many hours
Confidence and talkativeness
Reduced appetite
Suppressed need for sleep

Possible side effects

Severe crash and exhaustion afterwards
Raised heart rate, blood pressure and stroke risk
Anxiety, paranoia and psychosis with prolonged use
Sleep deprivation within a day or two of use
Severe dental and gum damage
Skin picking and sores
Weight loss and malnutrition
Strong dependence
Cardiac damage

Harm reduction

The order of risk in routes of use is broadly: smoking and injecting > nasal > oral. Do not escalate routes.
Sleep deprivation outruns the dose: 48+ hours awake plus methamphetamine is a standard route into psychosis.
Do not use alone, and tell someone how much you have taken and when.
Test for fentanyl; methamphetamine is also used as a cutting agent in other drugs.
Regular use causes dental, cardiac, cognitive and dermatological harm that is largely irreversible. Getting out early matters more than any dose adjustment.
Test your substance. Cocaine, amphetamine and MDMA powders are routinely cut with fentanyl or nitazenes, and stimulant pills are frequently counterfeits.
Do not mix stimulants with each other, with alcohol, or with MAOIs, SSRIs or tramadol - the cardiovascular and serotonin risks compound.
Watch body temperature. Overheating and dehydration cause more stimulant emergencies than heart attacks do. Take breaks, cool down with water and air, and sip (do not gulp) fluids.
Eat and sleep. Sleep deprivation plus stimulants is the standard route into stimulant psychosis.
Do not re-dose compulsively. Set a maximum before you start, and give it to someone else to hold you to.

Identify what you have

Marquis (TripSit reference)Deep reddish orange - Dark reddish brown

Marquis (reacts)red-orange > brown (116)

Mecke (reacts)yellow (67)

Mandelin (reacts)slow (dark) green (76)

Liebermann (reacts)orange reddish (28)

Froehdeclear or red (241)

Ehrlichno color change (168)

Robadopeno pink color change (121)

Simon's (reacts)instant dark blue (61)

Hofmannno color change (137)

Morris (reacts)pale green (77)

Scottno color change (65)

Folin (reacts)orange or pink (10)

Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.