DOSINA

Mescaline

Psychedelic

A long-acting psychedelic phenethylamine from cactus. Gentler and more bodily than LSD or psilocybin, with a 10-14 hour duration and significant nausea.

PeyoteSan PedroCactusButtonsbuttonsmescsansan-pedro

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0).

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.
⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold50 mg
Light50–200 mg
Common200–400 mg
Strong400–800 mg
Heavy / risk zone≥ 800 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (oral)

Onset45–90 minutes
Come-up60–120 minutes
Peak240–360 minutes
Offset120–180 minutes
Afterglow360–2160 minutes
Total480–840 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Vivid visuals and colour enhancement
  • Warmth and empathy
  • Insight
  • Euphoria
  • Altered sense of time

Possible side effects

  • Nausea and vomiting - very common on the come-up
  • Heavy body load
  • Anxiety
  • Insomnia
  • Raised heart rate and blood pressure
  • Long duration (10-14 hours) can be exhausting

Known toxicity

  • toxic dose is unknown

Harm reduction

  • Set and setting shape a psychedelic experience more than the dose does. Plan the room, the music, the company and the exit before you take anything.
  • Have a sober person present, or at minimum someone who knows what you have taken and can be called.
  • Do not redose to 'make it stronger'. Tolerance to psychedelics develops within an hour, so a redose mostly extends the experience and increases the risk of a difficult one.
  • Avoid combinations with lithium (seizure risk) and tramadol, and be extremely careful with cannabis, which sharply intensifies the experience.
  • People with a personal or family history of psychosis, schizophrenia or bipolar disorder should not use psychedelics - this is the clearest contraindication in the literature.
  • Never drive, cycle or operate machinery, and do not take psychedelics in public places or around crowds you cannot leave.
  • Physically: expect dilated pupils, raised heart rate and reduced appetite. These are normal. Chest pain, fainting or seizure activity is not - get help.
  • Frequency matters: repeated use within days has sharply diminishing returns and increases the risk of persistent visual disturbances.

Identify what you have

Marquis (TripSit reference)Strong orange

Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.

Mixing

ΑMTDangerous

See interaction notes for details.

amtDangerous

See interaction notes for details.

lithiumDangerous

There is a large number of reports indicating a high seizure and psychosis risk from this combination.

TramadolUnsafe

This combination can cause seizures due to the lowering of the threshold by tramadol and the potential of mescaline to cause seziures.

5-MeO-xxTCaution

The 5-MeO class of tryptamines can be unpredictable in their interactions

CannabisCaution

Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.

AmphetaminesCaution

The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops

CocaineCaution

The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops

MAOIsCaution

See interaction notes for details.

2c-t-xCaution

See interaction notes for details.

2c-xCaution

See interaction notes for details.

doxCaution

See interaction notes for details.

Tolerance, dependence and detection

Tolerancehalf tolerance after 3 days; back to baseline after 7 days
Addiction potentialnot habit-forming
After-effects3-5

Sources

• PsychonautWiki — Mescaline (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Mescaline

• TripSit wiki — Mescaline (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Mescaline.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.