DOSINA

Melatonin

Supplement

A naturally occurring hormone produced in the body, which promotes sleep at certain times in the day based on the circadian rhythm. It is also commonly available as a drug to treat insomnia and promote a proper sleep cycle. It can be used to promote sleepfulness at the tail-end of drug experiences, though it is not particularly hypnotic.

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Prescription or supplement entry — included for interaction checking, not as recreational dose guidance. Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.

Dose

Published population range

Threshold0.25 mg
Light0.5–1 mg
Common1–3 mg
Strong3–6 mg
Heavy / risk zone≥ 6 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (oral)

Onset5–20 minutes
Come-up20–70 minutes
Peak60–120 minutes
Offset120–180 minutes
Total180–360 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Sleepiness and easier sleep onset

Possible side effects

  • Daytime drowsiness
  • Vivid dreams
  • Headache
  • Additive sedation with alcohol or depressants

Known toxicity

  • extremely low toxicity

Harm reduction

  • Supplements are not risk-free. St John's Wort, 5-HTP, MAO-B and MAO-A inhibitors interact seriously with recreational drugs.
  • Never take 5-HTP at the same time as MDMA or other serotonin releasers - the combination is implicated in serotonin syndrome. At most it is used in the days after, and even that is debated.
  • Melatonin and L-theanine are sedating; that is fine for sleep but adds to depressant load if you have been drinking.
  • Dose information here reflects general-use amounts from the sources, not an endorsement of using them in combination with other drugs.

Identify what you have

Marquisno color change (254)
Meckeno color change (221)
Liebermann (reacts)light brown (113)
Froehdeno color change (241)
Ehrlich (reacts)reddish > purple (22)
Simon'sno blue color change (163)
Hofmann (reacts)yellow / orange > green (18)
Zimmermann (reacts)orange (2)
Morris (reacts)pale green (77)

Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.

Tolerance, dependence and detection

Tolerancehalf tolerance after 7 days; back to baseline after 14 days
Addiction potentialnot habit-forming

Sources

• PsychonautWiki — Melatonin (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Melatonin

• TripSit wiki — Melatonin (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Melatonin.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.