DOSINA

Kratom

Opioid

A plant opioid-receptor agonist used for pain, energy and self-managed opioid withdrawal. Mild at low doses, but dependence is real and withdrawal is unpleasant.

Mitragyna Speciosaกระท่อม (Thai)KetumKratum

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0).

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.
⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold1 g
Light2–3 g
Common3–5 g
Strong5–8 g
Heavy / risk zone≥ 8 g

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (oral)

Onset20–40 minutes
Peak60–120 minutes
Offset180–360 minutes
Total120–240 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Mild euphoria and wellbeing
  • Stimulation and energy at lower doses
  • Analgesia
  • Relaxation at higher doses
  • Relief from opioid withdrawal

Possible side effects

  • Dependence and difficulty stopping
  • Withdrawal (anxiety, restlessness, runny nose, insomnia)
  • Nausea
  • Constipation
  • Dizziness
  • Rare liver injury
  • Seizures reported rarely
  • Unknown interactions with other drugs

Known toxicity

  • low toxicity

Harm reduction

  • Never use alone. The single most effective thing you can do is have someone with you or on the phone.
  • Carry naloxone and know how to use it. It reverses opioid overdose and cannot harm someone who has not taken opioids.
  • Use fentanyl and nitazene test strips on every batch, including pills. They catch a large share of contamination, though not all of it.
  • Start with a fraction of your usual amount when you get a new batch or after any break in use - tolerance drops fast, in days.
  • Do not mix with benzodiazepines, alcohol, GHB or other sedatives. That combination is behind the majority of opioid deaths.
  • If someone is unresponsive: call emergency services, give naloxone, put them in the recovery position and stay with them. Naloxone wears off before many opioids do, so a second dose may be needed.
  • Prescribed opioid medication should never be shared or stockpiled - tolerance differences make it lethal.

Mixing

AlcoholDangerous

See interaction notes for details.

BenzodiazepinesDangerous

See interaction notes for details.

DXMDangerous

See interaction notes for details.

GHBDangerous

See interaction notes for details.

KetamineDangerous

See interaction notes for details.

MXEDangerous

See interaction notes for details.

TramadolDangerous

See interaction notes for details.

GrapefruitDangerous

See interaction notes for details.

MAOIsCaution

See interaction notes for details.

NitrousCaution

See interaction notes for details.

PCPCaution

See interaction notes for details.

StimulantsCaution

See interaction notes for details.

Tolerance, dependence and detection

Tolerancehalf tolerance after 3 - 7 days; back to baseline after 1 - 2 weeks
Addiction potentialproduces dependence with chronic use and has a high abuse potential
Detection windowKratom use is not detected by typical drug screening tests, but its metabolites can be detected by more specialized testing.
After-effects1-12

Sources

• PsychonautWiki — Kratom (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Kratom

• TripSit wiki — Kratom (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Kratom.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.