Ketamine
Dissociative · popular
A dissociative anaesthetic: disconnection from the body and senses, analgesia, and at high doses a total 'k-hole' experience. Rapid tolerance, and with heavy use, serious and sometimes irreversible bladder damage.
Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0).
Before you dose
Dose
Published population range
Basis: Scaled from the published 70 kg range; clinically, anaesthetic dosing is 1-2 mg/kg and recreational insufflation commonly lands at 0.5-1 mg/kg.
Ketamine tolerance climbs fast and does not fully reset, so doses drift upward with repeated use. That drift is what causes bladder damage.
Showing published ranges.
Check an amount you already have
Timeline (insufflated)
Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.
Expected effects
- Dissociation and detachment from the body
- Euphoria
- Analgesia (reduced pain)
- Visual and spatial distortion
- Dream-like state
- Time distortion
- Reduced anxiety
- Floating or flying sensations
Possible side effects
- Loss of coordination - falls and injuries
- Nausea and vomiting
- Raised heart rate and blood pressure
- Confusion and disorientation
- Bladder pain, urgency and frequency with heavy use (sometimes permanent)
- Severe abdominal cramps ('K-cramps')
- Muscle rigidity at high doses
- Amnesia for the experience
- Rapid tolerance that does not fully reset
Harm reduction
- Sit or lie down before it hits, somewhere you cannot fall. Injuries during the come-up are common.
- Never mix with alcohol, opioids, GHB or benzodiazepines - the combined respiratory depression is what kills people.
- Do not do it in or near water, on stairs, or standing in a kitchen.
- Bladder damage is cumulative. Burning, urgency, frequency or blood in urine means stop and get medical help.
- Tolerance rises fast and does not fully reset - escalating doses are a warning sign, not progress.
- If you are using regularly, take long breaks and keep the dose from creeping up.
- Dissociation removes your sense of where your body is. Sit or lie down in a safe, warm place, away from stairs, balconies, bathtubs, roads and open water.
- Never mix dissociatives with alcohol, GHB/GBL, benzodiazepines or opioids - that combination causes respiratory depression and deaths.
- Do not use alone, and do not use in a bathtub or swimming pool at any dose.
- Start with a fraction of the dose you think you need. Control and coordination go before you notice they have gone.
Identify what you have
Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.
Mixing
Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
See interaction notes for details.
No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
MAO-B inhibitors appear to increase the potency of Ketamine. MAO-A inhbitors have some negative reports associated with the combination but there isn't much information available
See interaction notes for details.
See interaction notes for details.
See interaction notes for details.
See interaction notes for details.
Tolerance, dependence and detection
Sources
• PsychonautWiki — Ketamine (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Ketamine
• TripSit wiki — Ketamine (PolyForm Noncommercial)
https://wiki.tripsit.me
• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Ketamine.shtml
Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.