DOSINA

Diphenhydramine

Deliriant

An antihistamine that becomes a deliriant at high doses. Historically misused as a cheap hallucinogen, it usually produces fear, confusion and an inability to recognise that what you are seeing is not real.

DPHBenadrylNytolSominexUnisom SleepMeltsZzzQuildphbenadryl

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0).

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.
⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold25 mg
Light100–200 mg
Common200–400 mg
Strong400–700 mg
Heavy / risk zone≥ 700 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (oral)

Onset30–90 minutes
Come-up45–90 minutes
Peak60–240 minutes
Offset120–360 minutes
Afterglow-–1440 minutes
Total180–600 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Sedation
  • Heavy, drowsy body feeling

Possible side effects

  • Delirium and hallucinations that are usually frightening
  • Inability to tell delusion from reality
  • Dry mouth and skin
  • Racing heart and high blood pressure
  • Urinary retention
  • Overheating
  • Seizures at higher doses
  • Amnesia

Known toxicity

  • fatal at amounts close to or exceeding 2 grams

Harm reduction

  • Deliriants are the least recreational and most dangerous class in this app. Effects are usually frightening, and users cannot reliably tell delusion from reality.
  • Anticholinergic overdose - from DPH, dimenhydrinate or datura - causes seizures, dangerous overheating, heart rhythm problems and death. There is no safe ceiling once you are past the therapeutic dose.
  • Datura and scopolamine have killed people at doses nobody could predict. Plant potency varies enormously between leaves and between plants.
  • Never use these alone, and never in a place where you could wander into traffic, water or a height.
  • If someone is confused, hot, dry-skinned and has a racing heart after taking any of these, that is a medical emergency - call for help and say what was taken.

Identify what you have

Froehde (reacts)orange (16)

Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.

Mixing

ghb/gblDangerous

Both substances are CNS depressants, potentiating each other strongly and unpredictably, raising the chances of memory loss, severe ataxia, and unconsciousness. The interaction will cause greater inhibition and risk of injury. If the user falls unconscious it is strongly recommended to put them into the recovery position and monitor breathing.

Tolerance, dependence and detection

Toleranceback to baseline after 1 - 2 weeks
Addiction potentialproduces dependence with chronic use
After-effects1-12

Sources

• PsychonautWiki — Diphenhydramine (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Diphenhydramine

• TripSit wiki — Diphenhydramine (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Diphenhydramine.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.