DOSINA

Dextromethorphan

Dissociative

A cough suppressant that becomes a dissociative hallucinogen at high doses. Plateaus range from buzzy to fully dissociated; potent CYP2D6 interactions make the dose-response unpredictable between people.

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Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0).

Before you dose

⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold75 mg
Light100–200 mg
Common200–400 mg
Strong400–700 mg
Heavy / risk zone≥ 700 mg

Basis: Scaled from the published 70 kg range. Clinical antitussive dosing is 0.5-1 mg/kg, far below recreational plateaus.

DXM plateaus are defined by absolute mg, not by body mass, so treat the scaled numbers as guidance rather than gospel.

Showing published ranges.

Check an amount you already have

Timeline (oral)

Onset30–120 minutes
Come-up60–120 minutes
Peak180–360 minutes
Offset120–240 minutes
Afterglow240–1440 minutes
Total480–720 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Dissociation
  • Euphoria
  • Visual and auditory changes
  • Music enhancement
  • Altered time perception
  • Analgesia

Possible side effects

  • Nausea and vomiting
  • Dizziness and double vision
  • Robotic movement and loss of coordination
  • Itching and flushing
  • Raised heart rate and blood pressure
  • Amnesia
  • Confusion and panic at higher plateaus
  • Serotonin syndrome risk when combined with serotonergic drugs
  • Psychosis at high doses

Known toxicity

  • exact toxic dosage is unknown

Harm reduction

  • Dissociation removes your sense of where your body is. Sit or lie down in a safe, warm place, away from stairs, balconies, bathtubs, roads and open water.
  • Never mix dissociatives with alcohol, GHB/GBL, benzodiazepines or opioids - that combination causes respiratory depression and deaths.
  • Do not use alone, and do not use in a bathtub or swimming pool at any dose.
  • Start with a fraction of the dose you think you need. Control and coordination go before you notice they have gone.
  • Frequent use of ketamine and similar drugs causes real bladder and urinary tract damage; early warning signs are pain, frequency and blood in urine.
  • Tolerance builds quickly and does not fully reset, which is how people end up at doses that were never safe to begin with.
  • Have someone check on you every 15-20 minutes during the peak, especially if you are lying down.

Mixing

ΑMTDangerous

See interaction notes for details.

PCPDangerous

See interaction notes for details.

MDMADangerous

See interaction notes for details.

AlcoholDangerous

Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the affected individual in the recovery position to prevent vomit aspiration from excess. Additionally, CNS depression can lead to difficulty breathing. Avoid on anything higher than 1st plateau.

GHBDangerous

Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the individual falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. This combination is hard to predict

OpioidsDangerous

CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes DXM, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.

TramadolDangerous

See interaction notes for details.

MAOIsDangerous

High risk of serotonin syndrome

SSRIsDangerous

High risk of serotonin syndrome.

AntihistaminesDangerous

See interaction notes for details.

amtDangerous

See interaction notes for details.

DOxUnsafe

The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.

Tolerance, dependence and detection

Tolerancehalf tolerance after 3 - 7 days; back to baseline after 1 - 2 weeks
Addiction potentialproduces dependence with chronic use and has moderate abuse potential
After-effects1-12

Sources

• PsychonautWiki — Dextromethorphan (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Dextromethorphan

• TripSit wiki — Dextromethorphan (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_DXM.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.