DOSINA

Cocaine

Stimulant · popular

A short-acting stimulant that blocks dopamine and noradrenaline reuptake. Intense confidence and euphoria for 20-45 minutes, followed by a crash and a strong compulsion to re-dose. Highest risks are cardiac - heart attack and stroke - especially when mixed with alcohol.

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Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0).

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.
⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold5 mg
Light10–30 mg
Common30–60 mg
Strong60–90 mg
Heavy / risk zone≥ 90 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (insufflated)

Onset3–10 minutes
Come-up5–12 minutes
Peak7.5–16 minutes
Offset10–25 minutes
Total10–90 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Intense euphoria
  • Confidence and talkativeness
  • Energy and alertness
  • Reduced appetite
  • Increased libido
  • Very reduced need for sleep

Possible side effects

  • Strong compulsion to re-dose
  • Raised heart rate and blood pressure
  • Chest pain and heart attack risk
  • Nosebleeds and damage to the nasal septum
  • Anxiety and paranoia
  • Insomnia and then exhaustion
  • Crash and low mood after use
  • Vasoconstriction (cold, pale extremities)
  • Stroke risk
  • Seizures at high doses

Known toxicity

  • individuals have died from as little as 30 mg applied to mucous membranes, whereas addicts may tolerate up to 5 grams daily

Harm reduction

  • Test for fentanyl and nitazenes, and be aware that stimulant powders are the most commonly contaminated category.
  • Do not drink while using. Alcohol plus cocaine forms cocaethylene in the liver, which is more cardiotoxic than either alone.
  • Chest pain, severe headache, one-sided weakness or slurred speech means emergency services, not sleep it off.
  • The compulsion to re-dose is a pharmacological effect, not a decision you are making freely. Set a hard stop and tell someone.
  • Nasal use damages the septum. Alternate nostrils, rinse with saline, and do not share straws or notes (hepatitis and other infections travel that way).
  • Do not combine with other stimulants, MAOIs or tramadol.
  • Test your substance. Cocaine, amphetamine and MDMA powders are routinely cut with fentanyl or nitazenes, and stimulant pills are frequently counterfeits.
  • Do not mix stimulants with each other, with alcohol, or with MAOIs, SSRIs or tramadol - the cardiovascular and serotonin risks compound.
  • Watch body temperature. Overheating and dehydration cause more stimulant emergencies than heart attacks do. Take breaks, cool down with water and air, and sip (do not gulp) fluids.
  • Eat and sleep. Sleep deprivation plus stimulants is the standard route into stimulant psychosis.

Identify what you have

Marquis (TripSit reference)Clear (No change)
Marquisno color change (254)
Meckeno color change (221)
Mandelin (reacts)short reddish (234)
Liebermann (reacts)yellow / orange (89)
Froehdeno color change (241)
Ehrlichno color change (168)
Simon'sno blue color change (163)
Hofmannno color change (137)
Zimmermannno color change (54)
Morris (reacts)pale green (77)
Folinno color change (15)

Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.

Mixing

ΑMTDangerous

See interaction notes for details.

OpioidsDangerous

Stimulants increase respiration rate allowing for a higher dose of opiates than normal. If the stimulant wears off first then the opiate may overcome the individual and cause respiratory arrest.

TramadolDangerous

Tramadol and stimulants both increase the risk of seizures.

MAOIsDangerous

This combination is poorly explored

amtDangerous

See interaction notes for details.

DOxUnsafe

The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic

25x-NBOMeUnsafe

See interaction notes for details.

2C-T-xUnsafe

Cocaine and 2c-t-x both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.

5-MeO-xxTUnsafe

The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.

DXMUnsafe

See interaction notes for details.

PCPUnsafe

This combination can easily lead to hypermanic states

AlcoholUnsafe

Cocaine can decrease some of the intoxicating effects of alcohol, causing some people to drink more than they otherwise would, which leads to greater behavioral and physical health risks. There is also some debate about cocaethylene, a metabolite produced when combining alcohol and cocaine, with some researchers positing that it is more cardiotoxic than cocaine on its own. Use moderation when combining these substances.

Tolerance, dependence and detection

Tolerancehalf tolerance after 3 - 7 days; back to baseline after 1 - 2 weeks
Addiction potentialhighly addictive with a high potential for abuse
Detection windowSaliva: 1 day, Urine: 4-5 days, Hair: up to 90 days
After-effects1-4

Sources

• PsychonautWiki — Cocaine (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Cocaine

• TripSit wiki — Cocaine (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Cocaine.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.