DOSINA

Clonidine

Medication

A blood-pressure medicine that is sedating. Included because that sedation adds to the load of any other depressant.

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Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Prescription or supplement entry — included for interaction checking, not as recreational dose guidance. Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.
⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold25 μg
Light50–75 μg
Common75–100 μg
Strong100–300 μg
Heavy / risk zone≥ 300 μg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (oral)

Onset15–45 minutes
Peak60–90 minutes
Offset360–480 minutes
Total360–480 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Lowered blood pressure, sedation (prescription medicine)

Possible side effects

  • Sedation
  • Dry mouth
  • Rebound hypertension if stopped abruptly
  • Additive sedation with depressants

Harm reduction

  • Dosina shows prescription medicines so their interactions are visible - not so you can use them recreationally.
  • Never stop a prescribed medicine abruptly to take something else. Antidepressant discontinuation syndrome is real and can be severe; talk to your prescriber first.
  • SSRIs, SNRIs, MAOIs, lithium and tricyclics all interact with recreational drugs in ways that range from 'wastes your money' to 'kills you'.
  • Serotonin syndrome is the emergency to watch for: agitation, confusion, tremor, sweating, muscle rigidity, fever and a fast heartbeat after combining serotonergic drugs. It can become fatal within hours.
  • Keep any prescription medicine in its original packaging and never share it.

Mixing

DepressantsDangerous

See interaction notes for details.

DissociativesDangerous

See interaction notes for details.

StimulantsCaution

See interaction notes for details.

Tolerance, dependence and detection

Addiction potentialnot addictive and has a low potential for abuse
After-effects1-4

Sources

• PsychonautWiki — Clonidine (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Clonidine

• TripSit wiki — Clonidine (PolyForm Noncommercial)
https://wiki.tripsit.me

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.