DOSINA

Caffeine

Stimulant · popular

The most widely used psychoactive substance in the world. Alertness and reduced fatigue at usual doses; anxiety, palpitations and insomnia at higher ones. Overdose is possible with powders and energy drinks.

coffee

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0).

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.

Dose

Published population range

Threshold2.5 mg
Light10–25 mg
Common25–40 mg
Strong40–80 mg
Heavy / risk zone≥ 80 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (insufflated)

Onset0.5–2 minutes
Come-up0.5–2 minutes
Peak30–60 minutes
Offset360–600 minutes
Afterglow360–1440 minutes
Total60–150 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Alertness
  • Reduced fatigue
  • Improved focus
  • Mild mood lift

Possible side effects

  • Anxiety and jitteriness
  • Insomnia
  • Raised heart rate and palpitations
  • Stomach upset and reflux
  • Headache during withdrawal
  • Dependence
  • Dangerous arrhythmias with pure caffeine powder

Known toxicity

  • The LD50 of caffeine in humans is dependent on individual sensitivity, but is estimated to be about 150 to 200 milligrams per kilogram of body mass or roughly 80 to 100 cups of coffee for an average adult

Harm reduction

  • Test your substance. Cocaine, amphetamine and MDMA powders are routinely cut with fentanyl or nitazenes, and stimulant pills are frequently counterfeits.
  • Do not mix stimulants with each other, with alcohol, or with MAOIs, SSRIs or tramadol - the cardiovascular and serotonin risks compound.
  • Watch body temperature. Overheating and dehydration cause more stimulant emergencies than heart attacks do. Take breaks, cool down with water and air, and sip (do not gulp) fluids.
  • Eat and sleep. Sleep deprivation plus stimulants is the standard route into stimulant psychosis.
  • Do not re-dose compulsively. Set a maximum before you start, and give it to someone else to hold you to.
  • Chest pain, severe headache, one-sided weakness, slurred speech or fainting are medical emergencies. Call for help immediately.
  • Nasal use damages the septum and sinuses; chronic use causes permanent damage that does not heal.

Identify what you have

Marquisno color change (254)
Meckeno color change (221)
Mandelinno color change (139)
Liebermann (reacts)light yellow / yellow (91)
Froehdeno color change (241)
Ehrlichno color change (168)
Robadopeno pink color change (121)
Simon'sno blue color change (163)
Hofmannno color change (137)
Scottno color change (65)

Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.

Mixing

DOxCaution

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.

25x-NBOMeCaution

See interaction notes for details.

ΑMTCaution

See interaction notes for details.

PCPCaution

Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.

AmphetaminesCaution

This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.

MDMACaution

Caffiene is not really necessary with MDMA and increases any neurotoxic effects from MDMA

CocaineCaution

Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.

LithiumCaution

See interaction notes for details.

amtCaution

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.

dextromethorphanCaution

High doses of caffeine can potentially exacerbate anxiety, especially during a dissociative experience, due to its stimulating effects. This combination might also lead to physical discomfort. However, individual responses to caffeine can vary significantly, often influenced by factors like habitual versus occasional usage.

2c-t-xLow risk

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.

2c-xLow risk

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.

Tolerance, dependence and detection

Tolerancehalf tolerance after 3 - 7 days; back to baseline after 1 - 2 weeks
Addiction potentialdevelop with regular consumption, leading to cravings and withdrawal effects upon sudden cessation, but has low abuse potential
After-effects3-4

Sources

• PsychonautWiki — Caffeine (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Caffeine

• TripSit wiki — Caffeine (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Caffeine.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.