An antidepressant and smoking-cessation medicine. Included for interaction checking — it lowers the seizure threshold and interacts badly with stimulants, tramadol and cocaine.

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Not covered by PsychonautWiki — data comes from TripSit. Prescription or supplement entry — included for interaction checking, not as recreational dose guidance. Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

Dose

No structured dose data for this substance in our sources. Treat anything you read elsewhere with caution - unknown potency is the single biggest risk with novel substances.

Expected effects

• Mood stabilisation, smoking cessation (prescription medicine)

Possible side effects

• Lowers the seizure threshold
• Insomnia and agitation
• Anxiety
• Hypertension
• Dangerous with stimulants and tramadol

Harm reduction

• Dosina shows prescription medicines so their interactions are visible - not so you can use them recreationally.
• Never stop a prescribed medicine abruptly to take something else. Antidepressant discontinuation syndrome is real and can be severe; talk to your prescriber first.
• SSRIs, SNRIs, MAOIs, lithium and tricyclics all interact with recreational drugs in ways that range from 'wastes your money' to 'kills you'.
• Serotonin syndrome is the emergency to watch for: agitation, confusion, tremor, sweating, muscle rigidity, fever and a fast heartbeat after combining serotonergic drugs. It can become fatal within hours.
• Keep any prescription medicine in its original packaging and never share it.

Tolerance, dependence and detection

Sources

• TripSit wiki — Bupropion (PolyForm Noncommercial)
https://wiki.tripsit.me