Buprenorphine

Opioid

A semi-synthetic opioid analgesic also known as subutex. Often administered as Butrans patches, or in combination with Naloxone as Suboxone, a heroin replacement therapy drug. Will cause withdrawals if you have an opioid tolerance and don't wait long enough (typically around 48 hours) before taking this.

BuprenexSubutexButransCizdolAddnokTranstecsuboxonesubsbupe

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠Dose here depends overwhelmingly on your tolerance, not your body weight. A dose that is mild for a tolerant user can be fatal for someone else.

⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold0.2 mg

Light0.2–0.4 mg

Common0.4–0.8 mg

Strong0.8–1.5 mg

Heavy / risk zone≥ 1.5 mg

Basis: Partial agonist with a ceiling effect.

Precipitates withdrawal if taken too soon after a full agonist.

Check an amount you already have

Timeline (insufflated)

Onset30–60 minutes

Peak240–480 minutes

Afterglow1440–4320 minutes

Total480–840 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

Withdrawal suppression
Analgesia

Possible side effects

Precipitated withdrawal if taken too soon after a full agonist
Respiratory depression (especially with benzodiazepines)
Nausea
Constipation
Dependence

Known toxicity

low toxicity

Harm reduction

Never use alone. The single most effective thing you can do is have someone with you or on the phone.
Carry naloxone and know how to use it. It reverses opioid overdose and cannot harm someone who has not taken opioids.
Use fentanyl and nitazene test strips on every batch, including pills. They catch a large share of contamination, though not all of it.
Start with a fraction of your usual amount when you get a new batch or after any break in use - tolerance drops fast, in days.
Do not mix with benzodiazepines, alcohol, GHB or other sedatives. That combination is behind the majority of opioid deaths.
If someone is unresponsive: call emergency services, give naloxone, put them in the recovery position and stay with them. Naloxone wears off before many opioids do, so a second dose may be needed.
Prescribed opioid medication should never be shared or stockpiled - tolerance differences make it lethal.

Identify what you have

Marquis (reacts)violet or no color change (68)

Liebermannblack or no color change (121)

Froehde (reacts)slow purple (42)

Scottno color change (65)

Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.