Baclofen

Depressant

Also known as Lioresal, Baclofen is a GABAb receptor agonist and central nervous system depressant used to treat spasticity, and holds promise as a treatment for alcoholism. It exhibits mild intoxicating effects similar to phenibut or pregabalin.

Lioresalgablofen

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.

⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold5 mg

Light10–20 mg

Common20–50 mg

Strong50–100 mg

Heavy / risk zone≥ 100 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (oral)

Onset30–75 minutes

Come-up60–90 minutes

Peak60–120 minutes

Offset90–150 minutes

Afterglow360–720 minutes

Total480–840 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

Muscle relaxation
Sedation
Anxiolysis

Possible side effects

Sedation
Weakness
Dependence and withdrawal
Respiratory depression when mixed with depressants

Known toxicity

low toxicity
potentially lethal when mixed with depressants like alcohol, benzodiazepines or opioids

Harm reduction

Depressants are the class where mixing kills most often: alcohol, benzodiazepines, GHB/GBL and opioids all suppress breathing when combined.
Never use alone. If you use alone, set up a check-in call with someone who will call emergency services if you do not answer.
Measure liquid doses with a syringe. Bottle caps, teaspoons and 'glugs' are how people take ten times the intended dose.
Sedation can be delayed. Do not re-dose before you can feel the previous dose fully.
Do not stop daily benzodiazepine or alcohol use abruptly - withdrawal can cause seizures and is potentially fatal. Taper with medical help.
Signs that someone needs emergency help: breathing slower than one breath every 4-5 seconds, blue lips, snoring that will not stop, unrousable, vomiting while unconscious.

Identify what you have

Marquisno color change (254)

Liebermannno color change (73)

Froehdeno color change (241)

Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.