DOSINA

Alprazolam

Depressant · popular

A short-acting, high-potency benzodiazepine with a fast, anxiety-melting onset and a disproportionate reputation among counterfeit presses. Blackouts and rebound anxiety are common; the combination with opioids or alcohol is lethal.

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Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0).

Before you dose

⚠Dose here depends overwhelmingly on your tolerance, not your body weight. A dose that is mild for a tolerant user can be fatal for someone else.
⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold0.05 mg
Light0.05–0.25 mg
Common0.25–0.5 mg
Strong0.5–1 mg
Heavy / risk zone≥ 1 mg

Basis: Depends on tolerance and on what the tablet actually contains.

Counterfeit pressed bars frequently contain other benzodiazepines or nitazenes, so a '1 mg bar' may be 3 mg or something else entirely.

Check an amount you already have

Timeline (inhaled)

Onset0.1–0.2 minutes
Come-up5–10 minutes
Peak60–120 minutes
Offset120–180 minutes
Total240–300 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Rapid anxiety relief
  • Relaxation
  • Reduced inhibitions
  • Muscle relaxation
  • Sedation

Possible side effects

  • Memory loss and blackouts
  • Dependence and severe withdrawal (seizures)
  • Rebound anxiety between doses
  • Sedation and falls
  • Respiratory depression when mixed with opioids or alcohol
  • Paradoxical agitation in some people
  • Counterfeit tablets of unknown strength

Known toxicity

  • low toxicity
  • potentially lethal when mixed with depressants like alcohol, opioids, or barbiturates

Harm reduction

  • Depressants are the class where mixing kills most often: alcohol, benzodiazepines, GHB/GBL and opioids all suppress breathing when combined.
  • Never use alone. If you use alone, set up a check-in call with someone who will call emergency services if you do not answer.
  • Measure liquid doses with a syringe. Bottle caps, teaspoons and 'glugs' are how people take ten times the intended dose.
  • Sedation can be delayed. Do not re-dose before you can feel the previous dose fully.
  • Do not stop daily benzodiazepine or alcohol use abruptly - withdrawal can cause seizures and is potentially fatal. Taper with medical help.
  • Signs that someone needs emergency help: breathing slower than one breath every 4-5 seconds, blue lips, snoring that will not stop, unrousable, vomiting while unconscious.

Identify what you have

Marquisno color change (254)
Meckeno color change (221)
Mandelinno color change (139)
Liebermannno color change (73)
Zimmermann (reacts)slow blue / violet (1)
Morris (reacts)pale green (77)

Reagent tests show what a substance probably is, not how pure it is or what else is in the mix. Fentanyl and nitazene test strips are the only reliable check for those, and quantitative lab testing is better than both.

Mixing

DepressantsDangerous

See interaction notes for details.

DissociativesDangerous

See interaction notes for details.

StimulantsCaution

See interaction notes for details.

Tolerance, dependence and detection

Toleranceback to baseline after 7-14 days
Addiction potentialextremely physically and psychologically addictive
After-effects6-24

Sources

• PsychonautWiki — Alprazolam (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/Alprazolam

• TripSit wiki — Alprazolam (PolyForm Noncommercial)
https://wiki.tripsit.me

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.