DOSINA

5-MeO-DMT

Psychedelic

A powerful psychedelic tryptamine found in many species of plants and some toad venom, with a history of use by native South Americans spanning thousands of years. Has similar qualities to DMT and related tryptamines. Very potent. Orally active in combination with an MAOI.

The God MoleculeToadJaguar5meodmttoads5-meo5meo5-medmt

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.
⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold3 mg
Light5–8 mg
Common8–15 mg
Strong15–25 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Timeline (insufflated)

Onset1–10 minutes
Peak10–40 minutes
Offset30–60 minutes
Afterglow60–180 minutes
Total120–180 minutes

Bars show relative time in each phase, scaled to the total duration. Each phase keeps its colour in the list above.

Expected effects

  • Complete ego dissolution
  • Sense of unity or nothingness
  • Intense bliss

Possible side effects

  • Overwhelming fear and resistance
  • Nausea
  • Possible respiratory effects at high doses
  • Panic
  • Extremely dangerous with MAOIs
  • Unpredictable physical intensity

Known toxicity

  • toxic dose is unknown

Harm reduction

  • Set and setting shape a psychedelic experience more than the dose does. Plan the room, the music, the company and the exit before you take anything.
  • Have a sober person present, or at minimum someone who knows what you have taken and can be called.
  • Do not redose to 'make it stronger'. Tolerance to psychedelics develops within an hour, so a redose mostly extends the experience and increases the risk of a difficult one.
  • Avoid combinations with lithium (seizure risk) and tramadol, and be extremely careful with cannabis, which sharply intensifies the experience.
  • People with a personal or family history of psychosis, schizophrenia or bipolar disorder should not use psychedelics - this is the clearest contraindication in the literature.
  • Never drive, cycle or operate machinery, and do not take psychedelics in public places or around crowds you cannot leave.
  • Physically: expect dilated pupils, raised heart rate and reduced appetite. These are normal. Chest pain, fainting or seizure activity is not - get help.
  • Frequency matters: repeated use within days has sharply diminishing returns and increases the risk of persistent visual disturbances.

Mixing

aMTDangerous

See interaction notes for details.

MAOIsDangerous

See interaction notes for details.

PCPDangerous

See interaction notes for details.

AmphetaminesUnsafe

See interaction notes for details.

CocaineUnsafe

See interaction notes for details.

DXMUnsafe

See interaction notes for details.

TramadolUnsafe

See interaction notes for details.

2C-T-xCaution

See interaction notes for details.

2C-xCaution

See interaction notes for details.

CannabisCaution

See interaction notes for details.

DOxCaution

See interaction notes for details.

MDMACaution

See interaction notes for details.

Tolerance, dependence and detection

Tolerancehalf tolerance after 1 hour; back to baseline after 2 hours
Addiction potentialnon-addictive with a low abuse potential

Sources

• PsychonautWiki — 5-MeO-DMT (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/5-MeO-DMT

• TripSit wiki — 5-MeO-DMT (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_5MeODMT.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.