DOSINA

5-Hydroxytryptophan

Supplement

A serotonin precursor sold as a sleep and mood supplement. Included because combining it with MDMA or other serotonin releasers is implicated in serotonin syndrome.

5-HTPOxitriptanCincofarmLevothymLevotonineOxyfanTelesolTript-OHTriptum5htptryptophanl-tryptophan

Dose and effect data: PsychonautWiki (CC BY-SA 4.0) and TripSit (PolyForm Noncommercial 1.0.0). Prescription or supplement entry — included for interaction checking, not as recreational dose guidance. Less-used substance: fewer independent sources, so treat these numbers with extra caution.

Before you dose

⚠This substance's dose is not reliably weight-scaled - the ranges shown are population figures. Sensitivity varies far more between people than body mass explains.
⚠This substance has combinations that are life-threatening. Check the Interactions tab before mixing anything.

Dose

Published population range

Threshold25 mg
Light50–100 mg
Common100–300 mg
Strong300–500 mg
Heavy / risk zone≥ 500 mg

No weight-based model for this substance — published ranges only.

Check an amount you already have

Expected effects

  • Serotonin precursor sold as a sleep and mood supplement

Possible side effects

  • Serotonin syndrome if combined with MDMA, SSRIs, MAOIs or tramadol
  • Nausea
  • Drowsiness
  • Not a safe 'comedown aid' while serotonin-releasing drugs are still active

Harm reduction

  • Supplements are not risk-free. St John's Wort, 5-HTP, MAO-B and MAO-A inhibitors interact seriously with recreational drugs.
  • Never take 5-HTP at the same time as MDMA or other serotonin releasers - the combination is implicated in serotonin syndrome. At most it is used in the days after, and even that is debated.
  • Melatonin and L-theanine are sedating; that is fine for sleep but adds to depressant load if you have been drinking.
  • Dose information here reflects general-use amounts from the sources, not an endorsement of using them in combination with other drugs.

Mixing

SSRIsDangerous

See interaction notes for details.

SNRIsDangerous

See interaction notes for details.

Serotonin releasersDangerous

See interaction notes for details.

MAOIsDangerous

See interaction notes for details.

Tricyclic antidepressantsDangerous

See interaction notes for details.

TramadolDangerous

See interaction notes for details.

Sources

• PsychonautWiki — 5-Hydroxytryptophan (CC BY-SA 4.0)
https://psychonautwiki.org/wiki/5-Hydroxytryptophan

• TripSit wiki — 5-Hydroxytryptophan (PolyForm Noncommercial)
https://wiki.tripsit.me

• Erowid experience reports (external)
https://www.erowid.org/experiences/subs/exp_Tryptophan.shtml

Dosina is educational harm-reduction information, not medical advice. Doses are population ranges from published sources and cannot account for your tolerance, health conditions or what is actually in your substance. Possession and use may be illegal where you live.